Recombinant clostridium botulinum neurotoxins
US10030238B2 · kind B2 · utility
7Cited by
5References
21Claims
0Family size
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Key dates
| Filing date | Oct 31, 2013 |
| Grant date | Jul 24, 2018 |
| Priority date | — |
| Expiry date | Oct 31, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a nucleic acid sequence comprising a sequence of contiguous nucleotides, wherein said sequence of contiguous nucleotides has at least 90% sequence identity to the nucleic acid sequence of SEQ ID NO: 1, and wherein said sequence of contiguous nucleotides encodes a single-chain BoNT/E1 protein. The present invention also provides methods for producing soluble single-chain BoNT/E1 protein in an E. coli host cell, together with methods for producing soluble di-chain BoNT/E1 protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.