Patent · US Active

Method for the comparison of protein higher order structures

US10031143B2 · kind B2 · utility

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19Claims
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Inventors

Key dates

Filing dateMay 21, 2015
Grant dateJul 24, 2018
Priority date—
Expiry dateMay 21, 2035

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2560/00
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Some aspects of the disclosure include methods for comparing the higher order structures (HOS) of proteins using covalent labeling agents which allow for the direct comparison of changes in the HOS of protein therapeutics using mass spectrometry. The inventive methods can be used to access the effect of changing the process of producing and/or storing complex biologic compounds as well as determining if the HOS of a protein therapeutic has spontaneously changed during storage. Still other uses include comparing branded biologic therapeutic compounds to biosimilar compounds, and measuring changes in the aggregation states of proteins.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.