Patent · US Active

High-throughput mouse model for optimizing antibody affinities

US10034463B2 · kind B2 · utility

2Cited by

0References

23Claims

0Family size

Assignee

Children's Medical Center Corporation · US

Inventors

Frederick W. Alt · Cambridge, US
Hwei-Ling Cheng · Northborough, US
Ming Tian · Nanhu, CN

Key dates

Filing date	Jan 23, 2015
Grant date	Jul 31, 2018
Priority date	—
Expiry date	Jan 23, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2800/30
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.