Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same

US10034930B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• David B. Weiner · Yeadon, US
• Devon Shedlock · San Diego, US

Key dates

• Filing date: Feb 13, 2017
• Grant date: Jul 31, 2018
• Expiry date: Feb 13, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/14271
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.