Patent · US Active

Mercaptonicotinic acid compound and preparation method and use thereof

US10035771B2 · kind B2 · utility

1Cited by

0References

9Claims

0Family size

Assignee

INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES, PR CHINA · CN

Inventors

Hui Wang · Alishan, TW
Wannian Zhng · Shanghai, CN
Zhenyuan Miao · Beijing, CN
Tao Li · San Diego, US
Xiong LIU · Beijing, CN
Yuelin Wu · Beijing, CN
Sen Luo · Beijing, CN
Chunquan Sheng · Shanghai, CN
Xiaoxue Lu · Wuxi, CN
Jianzhong Yao · Shanghai, CN

Key dates

Filing date	May 19, 2014
Grant date	Jul 31, 2018
Priority date	—
Expiry date	May 19, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D213/803
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound could inhibit activity of botulinum toxin endopeptidase and tetanus toxin endopeptidase in vitro, which has a significant protective effect on botulinum toxin poisoning in mice, and can be used for preparing medicine intended to prevent and/or treat botulism, as well as to prevent botulinum toxin exposure and tetanus.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.