Stable formulations of immunoglobulin single variable domains

US10035862B2 · kind B2 · utility

Assignee

• Ablynx N.V. · BE

Inventors

• Yves Meyvis · Evergem, BE
• Veronique De Brabandere · Evergem, BE
• Hans Ulrichts · Kortrijk, BE
• Ann Brigé · Ertvelde, BE
• Filip Callewaert · Dentergem, BE

Key dates

• Filing date: May 16, 2014
• Grant date: Jul 31, 2018
• Expiry date: May 16, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to stable formulations of polypeptides, e.g. immunoglobulin single variable domains, in particular immunoglobulin single variable domains directed against von Willebrand Factor (vWF). The invention provides formulations which are stable upon storage for prolonged periods of time and over a broad range of temperatures. The formulations of the invention ensure a high stability of the polypeptide, allowing multiple freeze-thaw cycles without chemical or physical deterioration, and provide stability in relation to mechanical stress, such as shake, shear or stir stress. They are suitable for pharmaceutical and diagnostic preparations and compatible with pharmaceutically acceptable diluents.