Specific internalization of nanoparticles into protein cages
US10035990B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Dec 10, 2013 |
| Grant date | Jul 31, 2018 |
| Priority date | — |
| Expiry date | Apr 27, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2998
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a method to encapsulate nanoparticles into a protein cage by inserting the nanoparticles into the core through holes. Currently commercially available nanoparticles can be functionalized using the inventive method. The inventive hybrids have applications in biosensing and bioimaging. The use of an affinity between poly-histidine chains and nitrilotriacetic acid as chelating reagent to obtain the inventive cages and hybrid assemblies by the method according to the invention is shown in FIG. 1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.