Scavenger compounds for improved sequencing-by-synthesis
US10036011B2 · kind B2 · utility
2Cited by
12References
37Claims
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Key dates
| Filing date | Feb 8, 2017 |
| Grant date | Jul 31, 2018 |
| Priority date | — |
| Expiry date | Feb 8, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6869
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention discloses methods of applications of indole-3-propionic acid, L-carnitine and O-acetyl-L-carnitine in one or more different reactive steps of a sequencing-by-synthesis workflow. The reactive steps employing these compounds include, but are not limited to, cleaving, imaging, incorporating bases and washing. The use of these new compounds provides improved sequencing performance including, but not limited to, lower error rates, higher sequence outputs and/or longer read lengths.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.