Catalytic nucleic acid and gold nanoparticles for detection of biomolecules
US10036056B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Jun 12, 2013 |
| Grant date | Jul 31, 2018 |
| Priority date | — |
| Expiry date | Jun 12, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to catalytic nucleic acid molecule signal amplification combined with surface plasmon properties of gold nanoparticles to achieve simple and sensitive colorimetric detection of biological targets. The assays of the present invention have about 50 pM sensitivity without the need for purification steps, can detect multiple targets in parallel, and is easily adaptable to new targets. The methods of the present invention are capable of rapid detection of genetic targets for gonorrhea, syphilis, malaria, and hepatitis B infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.