Lambodies with high affinity and selectivity for glycans and uses therefor
US10036747B2 · kind B2 · utility
2Cited by
6References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 21, 2012 |
| Grant date | Jul 31, 2018 |
| Priority date | — |
| Expiry date | Dec 22, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2400/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to dimeric proteins comprised of subunits having (i) recombinant lamprey variable lymphocyte receptor (VLR) diversity regions linked to (ii) multimerization domains. The dimeric proteins exhibit binding specificity for glycosylated antigens, and they may be used in methods of detecting or isolating glycans from a sample, and in methods of disease diagnosis, prognosis, progression monitoring, treatment, and imaging.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.