Material and method for treating internal cavities

US10039832B2 · kind B2 · utility

Assignee

• UroGen Pharma Ltd. · IL

Inventors

• Asher Holzer · Haifa, IL
• Dorit Daniel · Raanana, IL
• Michael Mullerad · Nes Ziona, IL
• Jaime De La Zerda · Haifa, IL
• Uri Shpolansky · Pardes Hana-Karkur, IL
• Nadav Malchi · Pardes Hana-Karkur, IL
• Yosh Dollberg · Raanana, IL
• Dor Tal · Hadera, IL
• Yossi Yavin · Ashkelon, IL
• Marina Konorty · Herzliya, IL

Key dates

• Filing date: May 22, 2015
• Grant date: Aug 7, 2018
• Expiry date: May 22, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y304/24069
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.