Compounds that participate in cooperative binding and uses thereof

US10039839B2 · kind B2 · utility

Assignee

• Warp Drive Bio, Inc. · US

Inventors

• Gregory L. Verdine · Boston, US
• Matthew James Nichols · Boston, US
• Dylan Talbot Stiles · Cambridge, US
• Neville J. Anthony · Hatfield, US
• Brian Roger Bowman · New Rochelle, US
• Mathew Edward Sowa · Watertown, US
• Sharon Ann Townson · Somerville, US

Key dates

• Filing date: Jan 8, 2016
• Grant date: Aug 7, 2018
• Expiry date: Jan 8, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/645
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to macrocyclic compounds capable of modulating biological processes through binding to a presenter protein and a target protein. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of intracellular target proteins. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of the targeted protein's activity. In some embodiment, the compounds of the invention “re-program” the binding of the presenter proteins to protein targets that either do not normally bind to the presenter protein.