Opsin-binding ligands, compositions and methods of use
US10040749B2 · kind B2 · utility
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Key dates
| Filing date | Nov 29, 2012 |
| Grant date | Aug 7, 2018 |
| Priority date | — |
| Expiry date | Nov 29, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.