B-cell receptor complex binding proteins containing T-cell epitopes

US10040827B2 · kind B2 · utility

Assignee

• Deutsches Krebsforschungszentrum · DE

Inventors

• Henri-Jacques Delecluse · Heidelberg, DE
• Regina Feederle · Munich, DE
• Emmalene Bartlett · Eppelheim, DE

Key dates

• Filing date: Mar 19, 2013
• Grant date: Aug 7, 2018
• Expiry date: Mar 19, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/16234
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of CD22, CD19, CD20, and CD21, and b) an immunogenic peptide comprising at least one T-cell epitope for use in vaccination of a subject against B-cell hyperproliferation or for use in the modulation of the immune response in a subject. The present invention further relates to a polynucleotide and a vector encoding said polypeptide and a host cell comprising the same. It also relates to a method for the stimulation of antigen-specific T-cells, comprising a) contacting antigen presenting cells (APC) with a polypeptide, the polynucleotide, or the vector of the invention, b) contacting said APC with T-cells, and c) thereby stimulating antigen-specific T-cells specific for said at least one T-cell epitope; to a method for immunizing a subject against B-cell hyperproliferation, to a method for immunizing a subject against an infectious agent, and to a method for inducing tolerance in a subject.