Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same

US10040828B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• David B. Weiner · Yeadon, US
• Daniel Choo · Lansdale, US
• Karuppiah Muthumani · Cherry Hill, US
• Nyamekye Obeng-Adjei · Lansdowne, US
• Veronica Scott · Philadelphia, US

Key dates

• Filing date: Apr 10, 2013
• Grant date: Aug 7, 2018
• Expiry date: Jan 28, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18534
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode an RSV immunogen are disclosed. Nucleic acid are disclosed that comprise the sequences that encodes consensus RSV F protein or immunogenic fragment thereof, sequences that encodes an RSV G(A) protein or immunogenic fragment thereof and sequences that encodes an RSV G(B) protein or immunogenic fragment thereof. Compositions comprising one, combinations of two or all three sequences are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Nucleic acid molecules and compositions comprising the chemokine CC20 and/or a consensus RSV M2-1 protein or immunogenic fragment thereof are also disclosed. Immunomodulatory methods and methods of inducing an immune response against RSV are disclosed. Method of preventing RSV infection and methods of treating individuals infected with RSV are disclosed.