Nucleic acids and host cells expressing antibodies capable of binding to the coagulation factor XIa and uses thereof

US10040866B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Andreas Wilmen · Neunburg vorm Wald, DE
• Julia STRAßBURGER · Wuppertal, DE
• Frank Dittmer · Goldkronach, DE
• Michael Strerath
• Anja Buchmüller · Essen, DE
• Joanna Grudzinska-Goebel · Berlin, DE
• Ricarda Finnern · Aachen, DE
• Martina Schäfer · Berlin, DE
• Christoph Gerdes
• Hannah Jörißen · Heiligenhaus, DE
• Asako Itakura · Portland, US
• Philberta Leung · San Francisco, US
• Erik I. Tucker · Portland, US

Key dates

• Filing date: Aug 30, 2017
• Grant date: Aug 7, 2018
• Expiry date: Aug 30, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.