Patent · US Active

Highly diverse combinatorial antibody libraries

US10040870B2 · kind B2 · utility

5Cited by

0References

4Claims

0Family size

Assignee

argenx BVBA · BE

Inventors

Johannes Joseph Wilhelmus De Haard · Vlaardingen, NL
Christophe Blanchetot · Laarne, BE
Alex Klarenbeek · IJsselstein, NL
Ikbel Achour · Gaithersburg, US
Khalil El Mazouari · Vinderhoute, BE
Jurgen DEL FAVERO · Niel, BE

Key dates

Filing date	Sep 2, 2013
Grant date	Aug 7, 2018
Priority date	—
Expiry date	Aug 7, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/24
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed is an immune library obtained from a Camelid species containing at antibody chains belonging to at least 7 human germline antibody chains. The presence of a large number of human germline antibody chain families in the library contributes to the usefulness of the library in producing antibodies to human target antigens. The antibodies produced from the library have low inherent immunogenicity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.