Patent · US Active

Method for endotoxin removal

US10041050B2 · kind B2 · utility

0Cited by

6References

20Claims

0Family size

Assignee

GE Healthcare BioProcess R&D AB · SE

Inventors

Patrik Adielsson · Uppsala, SE
Tobias Soderman · Uppsala, SE
Anna Akerblom · Uppsala, SE

Key dates

Filing date	Nov 18, 2016
Grant date	Aug 7, 2018
Priority date	—
Expiry date	Nov 18, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2760/16151
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target molecule(s) with a chromatography media comprising beads having an inner porous core functionalized with ligands capable of binding endotoxin and an outer porous layer without functional groups and a pore size small enough to exclude the target molecule from the inner core; and collecting the sample from the media, wherein the sample comprises an endotoxin level which is at least 75% less, preferably 90% less, than before the removal and the yield of the target molecule is at least 75%.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.