Spirocyclic compounds as tryptophan hydroxylase inhibitors
US10045988B2 · kind B2 · utility
8Cited by
4References
26Claims
0Family size
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Key dates
| Filing date | Jul 10, 2017 |
| Grant date | Aug 14, 2018 |
| Priority date | — |
| Expiry date | Jul 10, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.