Poly(thioketal-urethane) scaffolds and methods of use

US10046086B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• Scott A. Guelcher · Spring Hill, US
• Madison A.P. McGough · Nashville, US
• Mukesh K. Gupta · Nashville, US
• Craig L. Duvall · Nashville, US
• John R. Martin · Nashville, US
• Jon Page · Mount Juliet, US

Key dates

• Filing date: Oct 11, 2016
• Grant date: Aug 14, 2018
• Expiry date: Oct 11, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G2230/00
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups.