Methods for scale-up of continuous reactors
US10046295B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 7, 2012 |
| Grant date | Aug 14, 2018 |
| Priority date | — |
| Expiry date | Jun 26, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T29/49
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for scale-up of a micro reactor process from lab to production scale comprises using a wall material for a lab reactor having thermal conductivity ≤3 W/m·K, and using a wall material for a production reactor having thermal conductivity ≥5 W/m·K. Desirably, flow velocity is kept constant, and the height of the production-scale process channel is determined by: wherein A B and C are constants; HG is the overall volumetric heat transfer coefficient, Dh is the hydraulic diameter, λW is the thermal conductivity of the wall, b is the empirically determined power to which the Reynolds number is raised in the equation for the Nusselt criteria (Nu=a·RebPrc) for the type of flow used, and h is the height of the channel, all in the production-scale process; and HG0 is the overall volumetric heat transfer coefficient in the lab-scale process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.