RNA interference agents for GST-PI gene modulation
US10047111B2 · kind B2 · utility
9Cited by
10References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 28, 2015 |
| Grant date | Aug 14, 2018 |
| Priority date | — |
| Expiry date | Dec 28, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/53
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides compounds, compositions and methods for modulating the expression of human GST-π using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2′-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.