Amyloid-beta binding proteins

US10047121B2 · kind B2 · utility

Assignees

• Abb Vie Deutschland Gmbh & Co. KG · DE
• Abb Vie Inc. · US

Inventors

• Stefan Barghorn · Mannheim, DE
• Heinz Hillen · Herbrechtingen, DE
• Andreas Striebinger · Speyer, DE
• Simone Giaisi · Edingen-Neckarhausen, DE
• Ulrich Ebert · Mannheim, DE
• Chung-Ming Hsieh · Newton, US

Key dates

• Filing date: Jun 22, 2015
• Grant date: Aug 14, 2018
• Expiry date: Jun 22, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/41
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Λβ(20-42) globulomer or any Λβ form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.