Patent · US Active

Methods for producing fabs and bi-specific antibodies

US10047167B2 · kind B2 · utility

16Cited by

0References

21Claims

0Family size

Assignees

ELI LILLY AND COMPANY · US
The University of North Carolina at Chapel Hill · US

Inventors

Stephen Demarest · San Diego, US
Xiufeng Wu · San Diego, US
Brian Arthur Kuhlman · Chapel Hill, US
Steven Lewis · Santa Clara, US
Raheleh Toughiri · San Diego, US

Key dates

Filing date	Mar 12, 2014
Grant date	Aug 14, 2018
Priority date	—
Expiry date	Dec 4, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.