Grimonitia-hollisae-derived recombinant collagenase and enzyme agent for cell and tissue dissociation
US10047353B2 · kind B2 · utility
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Key dates
| Filing date | Mar 6, 2015 |
| Grant date | Aug 14, 2018 |
| Priority date | — |
| Expiry date | Mar 6, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/24007
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant collagenase is derived from Grimontia hollisae-derived collagenase is characterized by having, from the N terminus to the C terminus, a collagenase catalytic domain, a linker region sequence, and a prepeptidase C terminal domain, which Grimontia hollisae-derived recombinant collagenase does not comprise at least the prepeptidase C terminal domain. The obtained recombinant collagenase has a high and stable specific activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.