Integrated device with external light source for probing detecting and analyzing molecules

US10048208B2 · kind B2 · utility

Assignee

• Quantum-Si Incorporated · US

Inventors

• Jonathan M. Rothberg · Paradise, US
• Ali Kabiri · Guilford, US
• Jason W. Sickler · Arlington, US
• Brett J. Gyarfas · Guilford, US
• Jeremy Lackey · Foster City, US
• Gerard Schmid · Guilford, US
• Benjamin Cipriany · Branford, US
• Jack L. Jewell · Boulder, US
• Lawrence C. West · San Jose, US
• Michael Ferrigno · Farmington, US
• Paul E. Glenn · Wellesley, US
• Anthony Bellofiore · Glastonbury, US

Key dates

• Filing date: Nov 17, 2014
• Grant date: Aug 14, 2018
• Expiry date: Oct 18, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T29/49016
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.