Treatment of bioprosthetic tissues to mitigate post implantation calcification
US10053256B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 17, 2014 |
| Grant date | Aug 21, 2018 |
| Priority date | — |
| Expiry date | Jul 11, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/02
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Bioprosthetic tissues are treated by immersing or otherwise contacting fixed, unfixed or partially fixed tissue with a glutaraldehyde solution that has previously been heat-treated or pH adjusted prior to its contact with the tissue. The prior heat treating or pH adjustment of the glutaraldehyde solution causes its free aldehyde concentration to decrease by about 25% or more, preferably by as much as 50%, and allows a “stabilized” glutaraldehyde solution to be obtained at the desired concentration and pH for an optimal fixation of the tissue at high or low temperature. This treatment results in a decrease in the tissue's propensity to calcify after being implanted within the body of a human or animal patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.