Process for the synthesis of metyrapone and alkylated metyrapone analogs
US10053426B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Oct 5, 2015 |
| Grant date | Aug 21, 2018 |
| Priority date | — |
| Expiry date | Oct 5, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for preparing metyrapone type compounds are generally described herein. In particular, one step process for preparing metyrapone type compounds are described herein. Such processes generally include an alpha-carbon arylation coupling reaction between 3-isobutyrylpyridine and 3-halopyridine compounds in the presence of a palladium catalyst and a phosphine ligand to form the metyrapone-type compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.