Spirocyclic aryl phosphorus oxide and aryl phosphorus sulfide

US10053477B2 · kind B2 · utility

Assignee

• QILU PHARMACEUTICAL CO., LTD. · CN

Inventors

• Zhaozhong Ding · Shanghai, CN
• Minghui Zhang · Beijing, CN
• Shuhui CHEN · Shanghai, CN
• Xile LIU · Shanghai, CN
• Yidong Zhu · 红钢城街道, CN
• Chuanwen Fan · Shandong, CN
• Baoping Zhao · Shanghai, CN
• Long Zhang · Hunan, CN
• Yingying YANG · Jinan, CN
• Qingmei ZHENG · Jinan, CN
• Shansong ZHENG · Jinan, CN
• Haiwen Wan · Shanghai, CN
• Jinqing Hu · Shanghai, CN

Key dates

• Filing date: Jun 29, 2015
• Grant date: Aug 21, 2018
• Expiry date: Jun 29, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65615
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a spirocyclic aryl phosphorus oxide or sulfide as an ALK inhibitor, particularly, a compound represented by formula (I) as an ALK inhibitor or pharmaceutically acceptable salt thereof.