Molecularly imprinted polymer nanoparticles compatible with biological samples and preparation method thereof

US10053531B2 · kind B2 · utility

Assignee

• Nankai University · CN

Inventors

• Huiqi Zhang · Tianjin, CN
• Yue Ma · Shanghai, CN
• Ying Zhang · Salt Lake City, US
• Guoqing Pan · Tianjin, CN

Key dates

• Filing date: Nov 20, 2013
• Grant date: Aug 21, 2018
• Expiry date: Oct 14, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2600/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention provides molecularly imprinted polymer nanoparticles compatible with biological samples, and in particular pure biological samples and a preparation method thereof. Said molecularly imprinted polymer nanoparticles have a crosslinking degree exceeding 50%, a particle diameter of 10 to 500 nm, hydrophilic polymer brushes on its surfaces and can be prepared by introducing appropriate hydrophilic macromolecular chain transfer agents into reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization systems through the one-pot synthesis. The preparation method is simple, features a broad range of application and yields a pure product. The obtained hydrophilic molecularly imprinted polymer nanoparticles have prospects for a wide range of application in biological sample analysis, medical clinical immune analysis, food and environmental monitoring, biomimetic sensors, etc.