Compositions and methods comprising a defined microbiome and methods of use thereof

US10058576B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Frederic Bushman · Encinitas, US
• Gary Wu · Ardmore, US
• James Lewis · Moorestown, US
• Mark Goulian · Philadelphia, US

Key dates

• Filing date: Apr 4, 2016
• Grant date: Aug 28, 2018
• Expiry date: May 10, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention features the use of a defined microbial consortia for the replacement of a gut microbiome associated with disease. In particular, the invention provides for the treatment of hyperammonemia, Clostridium difficile colitis, hepatic encephalopathy associated with cirrhosis, and inflammatory bowel disease.