Lipids and lipid compositions for the delivery of active agents

US10059655B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Luis Brito · Cambridge, US
• Delai Chen · Cambridge, US
• Gabriel Grant Gamber · Cambridge, US
• Andrew Geall · Littleton, US
• Kevin Love · Somerville, US
• Thomas Zabawa · Boston, US
• Frederic Zecri · Cambridge, US

Key dates

• Filing date: Dec 17, 2014
• Grant date: Aug 28, 2018
• Expiry date: Dec 17, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18534
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, n and p are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.