Pyrimidines as sodium channel blockers

US10059675B2 · kind B2 · utility

Assignee

• PURDUE PHARMA L.P. · US

Inventors

• Chiyou Ni · Montgomery, US
• Laykea Tafesse · Robinsville, US
• Jiangchao Yao · Princeton, US
• Mark A. Youngman · Warminster, US
• Minnie Park · Princeton Junction, US
• Bin Shao · Shanghai, CN

Key dates

• Filing date: May 4, 2017
• Grant date: Aug 28, 2018
• Expiry date: May 4, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/506
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.