Process for the production of cannabidiol and delta-9-tetrahydrocannabinol

US10059683B2 · kind B2 · utility

Assignee

• NORAMCO, LLC · US

Inventors

• Lukas Dialer · Schaffhausen, CH
• Denis Petrovic · Schaffhausen, CH
• Ulrich Weigl · Hilzingen, DE

Key dates

• Filing date: Jun 30, 2016
• Grant date: Aug 28, 2018
• Expiry date: Jun 30, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/80
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be prepared by an acid-catalyzed reaction of a suitably selected and substituted di-halo-olivetol or derivative thereof with a suitably selected and substituted cyclic alkene to produce a dihalo-cannabidiol compound or derivative thereof. The dihalo-cannabidiol compound or derivative thereof can be produced in high yield, high stereospecificity, or both. It can then be converted under reducing conditions to a cannabidiol compound or derivatives thereof.