N-benzyl tryptanthrin derivative, and preparation method and application thereof
US10059712B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 12, 2014 |
| Grant date | Aug 28, 2018 |
| Priority date | — |
| Expiry date | Nov 12, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an N-benzyl tryptanthrin derivative, and preparation method and use thereof. The N-benzyl tryptanthrin derivative of the present invention is characterized in that the derivative has a structural general formula as represented by formula 1, wherein each group is defined as in the specification. The preparation method of the compound is simple, has mild conditions and high yield, and is suitable for industrial production. The N-benzyl tryptanthrin derivative has good indoleamine-2,3-dioxy-genase (IDO) inhibitory activity, and can be used for treating diseases having the pathological feature of IDO-mediated tryptophan metabolism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.