Interrogatory cell-based assays and uses thereof
US10061887B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 7, 2012 |
| Grant date | Aug 28, 2018 |
| Priority date | — |
| Expiry date | Nov 25, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/68
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Described herein are methods for identifying a modulator of a biological system. Some methods include establishing a model for the biological system comprising cells, obtaining a first data set representing global proteomic in the cells, and obtaining a second data set representing one or more functional activities or cellular responses of the cells including global enzymatic activity and/or an effect of the global enzyme activity on the enzyme metabolites or substrates in the cells. The method also includes generating a consensus causal relationship network among the global proteomic changes and the one or more functional activities or cellular responses based solely on the first and second data sets using a programmed computing device, and identifying a causal relationship unique in the biological system from the consensus causal relationship network, wherein at least one enzyme associated with the unique causal relationship is identified as a modulator of the biological system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.