Methods of populating a gastrointestinal tract

US10064900B2 · kind B2 · utility

Assignee

• Seres Therapeutics, Inc. · US

Inventors

• Geoffrey von Maltzahn · Boston, US
• Matthew R. Henn · Somerville, US
• David N. Cook · Lafayette, US
• David Arthur Berry · Brookline, US
• Noubar B. Afeyan · Lexington, US
• Brian Goodman · Brookline, US
• Mary-Jane Lombardo McKenzie · Arlington, US
• Marin Vulic · Boston, US

Key dates

• Filing date: Feb 4, 2014
• Grant date: Sep 4, 2018
• Expiry date: Feb 4, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions for populating the gastrointestinal tract of a subject are described. Methods include administering to a subject a therapeutic composition comprising a purified population of spore-forming bacteria produced by providing a fecal material and subjecting the material to a treatment step resulting in purification of spore-forming bacteria. Methods include administering an amount effective to engraft and/or augment in the gastrointestinal tract in order to treat or prevent a dysbiosis in the mammalian subject.