Substituted imidazo[4,5-c]pyridines as SSAO inhibitors

US10065954B2 · kind B2 · utility

Assignee

• PROXIMAGEN, LLC · US

Inventors

• Max Espensen · London, GB
• Lee Patient · Linton, US
• Edward Savory · Cambourne, GB

Key dates

• Filing date: Sep 17, 2015
• Grant date: Sep 4, 2018
• Expiry date: Sep 17, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Specific compounds of formula (Ia): and pharmaceutically acceptable salts thereof. Pharmaceutical compositions of the specific compounds of formula (Ia) and pharmaceutically acceptable salts thereof. A method for inhibiting tumor growth in a subject that includes administering to the subject an effective amount of a compound selected from the specific compounds of formula (Ia) and pharmaceutically acceptable salts thereof. A method for modulating semicarbazide-sensitive amine oxidase activity in a subject that includes administering to the subject an effective amount of a compound selected from the specific compounds of formula (Ia) and pharmaceutically acceptable salts thereof.