Patent · US Active

Dipeptide-repeat proteins as therapeutic target in neurodegenerative diseases with hexanucleotide repeat expansion

US10066007B2 · kind B2 · utility

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5Claims

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Assignee

DEUTSCHES ZENTRUM FUR NEURODEGENRATIVE ERKANKUNG · DE

Inventors

Dieter Edbauer · Germering, DE
Christian Haass · Icking, DE
Shih-Ming Weng · Taipei, TW
Kohji Mori · Sanyo Onoda, JP
Thomas Arzberger · Baldham, DE
Elisabeth Kremmer · Freising, DE

Key dates

Filing date	Jan 22, 2014
Grant date	Sep 4, 2018
Priority date	—
Expiry date	Feb 2, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates to a method of detecting a disease characterized by an expansion of genomic hexanucleotide repeats as well as polypeptides of said hexanucleotide repeats, ligands specifically binding to the polypeptides, and to methods of identifying an inhibitor preventing the expression and/or aggregation of said polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.