Microbial production of 3-hydroxypropionic acid
US10066245B2 · kind B2 · utility
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Key dates
| Filing date | Jun 12, 2014 |
| Grant date | Sep 4, 2018 |
| Priority date | — |
| Expiry date | Jun 12, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y102/01009
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.
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