[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds

US10071079B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Alaric J. Dyckman · Lawrenceville, US
• Dharmpal S. Dodd · Princeton, US
• John E. Macor · Guilford, US
• Christopher P. Mussari · Princeton, US
• Laxman Pasunoori · Warangal, IN
• Sreekantha Ratna Kumar · Bengaluru, IN
• Trevor C. Sherwood · Plainsboro, US
• Ramesh Kumar Sistla · Bengaluru, IN

Key dates

• Filing date: Jun 27, 2017
• Grant date: Sep 11, 2018
• Expiry date: Jun 27, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.