Combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation

US10071089B2 · kind B2 · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• Yvonne Von Coburg · Limburg, DE
• Karen Reimer · Diez, DE
• Alexander Oksche · Limburg, DE
• Peter Holzer · Obertraubling, DE

Key dates

• Filing date: Jul 23, 2014
• Grant date: Sep 11, 2018
• Expiry date: Jul 23, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is concerned with an oral pharmaceutical dosage form comprising oxycodone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof for use in the treatment of pain in patients suffering from i) pain and at least one further disease ii), wherein said at least one further disease ii) results in intestinal dysbiosis, or for use in the treatment of pain in patients suffering from i) pain and at least one further disease iii), wherein said at least one further disease iii) increases the risk for intestinal bacterial translocation and thus for peritonitis, SIRS and/or sepsis.