Systems and methods for tuning closed-loop phasic burst stimulation based on a phase response curve

US10071248B2 · kind B2 · utility

Assignees

• Regents of the University of Minnesota · US
• The Regents of the University of California · US

Inventors

• Theoden I. Netoff · Minneapolis, US
• Dan Wilson · West End, US
• Jeff Moehlis · Lompoc, US
• Abbey Holt Becker · Minneapolis, US

Key dates

• Filing date: Nov 7, 2016
• Grant date: Sep 11, 2018
• Expiry date: Nov 7, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/36178
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Systems and methods are provided for determining optimized settings for a closed-loop stimulation system based on analyzing a phase response curve measured from electrophysiological activity, such as electrical nerve activity or electrical muscle activity. The slope of the phase response curve is computed and used to determine a phase window during which phasic burst stimulation should be provided to achieve a desired effect on oscillations in the subject. When the slope of the phase response curve is positive, a phasic burst stimulation applied during the phase window will decrease synchrony of the oscillations. When the slope of the phase response curve is negative, a phasic burst stimulation applied during the phase window will increase synchrony of the oscillations.