Method for preparing peptides by assembling multiple peptide fragments
US10072041B2 · kind B2 · utility
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Key dates
| Filing date | Feb 15, 2012 |
| Grant date | Sep 11, 2018 |
| Priority date | — |
| Expiry date | Feb 12, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Method for preparing a peptide assembly of n fragments and n−1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci−1-Ai- . . . -Cn−1-An (I) in which A1, A2, A3, . . . Ai . . . , An are peptide fragments, C1, C2, C3 . . . Ci−1 . . . Cn−1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.