Patent · US Active

Sulfolobal phosphotriesterase-like (PLL) lactonases activity having enhanced properties and the uses thereof

US10072252B2 · kind B2 · utility

2Cited by

0References

22Claims

0Family size

Assignees

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
UNIVERSITÉ D'AIX-MARSEILLE · FR

Inventors

Eric Chabriere · Nancy, FR
Mikael Elias · Florange, FR
Julien Hiblot · Heidelberg, DE
Didier Raoult · Marseilles, FR

Key dates

Filing date	Apr 14, 2014
Grant date	Sep 11, 2018
Priority date	—
Expiry date	Sep 2, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y301/08
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.