STAT5 inhibitors and use thereof
US10072266B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Mar 20, 2015 |
| Grant date | Sep 11, 2018 |
| Priority date | — |
| Expiry date | Mar 20, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided is a composition of matter binding specifically to STAT5, preferably to STAT5B, including a nucleic acid aptamer, and methods of treatment of cancer, and in particular leukaemia via the inhibition of STAT5 protein. The present invention relates more particularly to specific aptamers of STAT5 protein, and the therapeutic or diagnostic use thereof. Also provided is a method for detecting STAT5 in a biological sample, including contacting a nucleic acid aptamer binding specifically to STAT5 with a sample taken beforehand from a subject and determining the quantity of said aptamer bound to said sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.