Salivary mRNA profiling, biomarkers and related methods

US10072297B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• David T. Wong · Newton, US
• Maie A. St. John · Los Angeles, US
• Yang Li · Shanghai, CN

Key dates

• Filing date: Feb 17, 2005
• Grant date: Sep 11, 2018
• Expiry date: Jul 13, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/6893
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting a transcriptome pattern in the cell-free saliva; a method to detect genetic alterations in an organ or in a gene in the organ by analyzing saliva, comprises detecting a transcriptome pattern and/or the mRNA profiling of the gene in cell-free saliva; a method to diagnose an oral or systemic pathology disease or disorder in a subject, comprises: detecting profile of a biomarker associated with the pathology disease or disorder, in particular mRNA and/or protein, in cell-free saliva and/or serum; kits comprising identifier for at least one biomarker for performing at least one of the methods; and use of salivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/or systemic pathology, disease or disorder.