Substituted pyridazines as skeletal muscle modulators

US10076519B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Luke W. Ashcraft · San Francisco, US
• Gustave Bergnes · Pacifica, US
• Scott Collibee · South San Francisco, US
• Chihyuan Chuang · Millbrae, US
• Jeff Gardina · South San Francisco, US
• Bradley P. Morgan · Moraga, US
• Alex Muci · South San Francisco, US
• Xiangping Qian · Foster City, US
• Jeffrey Warrington · San Mateo, US
• Zhe Yang · Daly City, US
• Pu-Ping Lu · Foster City, US
• Antonio Romero · San Mateo, US

Key dates

• Filing date: Mar 20, 2017
• Grant date: Sep 18, 2018
• Expiry date: Mar 20, 2037

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.