Patent · US Active

Bacterial artificial chromosomes

US10076564B2 · kind B2 · utility

0Cited by

4References

20Claims

0Family size

Assignee

Katholieke Universiteit Leuven · BE

Inventors

Kai Dallmeier · Kessel-Lo, BE
Johan Neyts · Namur, BE

Key dates

Filing date	Apr 25, 2014
Grant date	Sep 18, 2018
Priority date	—
Expiry date	Jun 12, 2034

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to the use of a bacterial artificial chromosome (BAC) for the preparation of a vaccine, wherein the BAC comprises an inducible bacterial ori sequence for amplification of the BAC to more than 10 copies per bacterial cell. Plus a viral expression cassette comprising a cDNA of an attenuated RNA virus genome and comprising cis-regulatory elements for transcription of said viral cDNA in mammalian cells and for processing of the transcribed RNA into infectious viral RNA.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.