Compositions and methods for treating endocrine, gastrointestinal or autoimmune disorders
US10076577B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 12, 2016 |
| Grant date | Sep 18, 2018 |
| Priority date | — |
| Expiry date | Feb 12, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/002
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Recombinant cells and methods are provided that relate to the use of isolated, engineered recombinant cells to directly or indirectly treat diseases or disorders in a mammalian host such as endocrine, gastrointestinal or autoimmune disorders. A recombinant cell is provided that comprises a signal sequence and a promoter, wherein: the signal sequence is capable of regulating signal-dependent expression of a target nucleic acid in a host or is capable of regulating signal-dependent expression of a target nucleic acid in response to an environmental stimulus, the cell is derived from an enteric or a commensal bacterium, and the target nucleic acid encodes a mammalian factor that promotes normal functioning of a physiological process in the host or is effective in preventing onset, establishment, or spread of a non-infectious disease in the host. The recombinant cell is administered to the host to treat the disease or disorder.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.